Research Associate in Statistical Bioinformatics @ NSW

Position title: Research Associate in Statistical Bioinformatics

Employer: University of Sydney

Closing date: 30th May 2023

Brief position description: Full time, 18 months fixed term. Located on the Camperdown Campus at the School of Mathematics and Statistics

Opportunity to make valuable contributions to research in statistical bioinformatics and biomedical data science

Base Salary Level A, $79,784 p.a. - $107,516 p.a. + 17% superannuation 

About the opportunity
We are one of the largest mathematical sciences schools in Australia, and the University of Sydney is the only Australian university to have received the highest rating of 5 out of 5 for research in the mathematical sciences in every Australian Research Council Excellence in Research for Australia assessment to date. The University also hosts the Sydney Mathematical Research Institute (SMRI), which attracts leading mathematical scientists from all over the world to do research with Australian collaborators.

We are seeking to appoint a Research Associate to work on a project entitled ‘Multiscale data integration for single cell spatial genomics’. The successful candidate will work under the supervision of Dr Shila Ghazanfar on developing new statistical and algorithmic techniques to understand single cell spatial genomics data. This project has recently been funded by the Chan Zuckerberg Initiative.

Technological advances in measuring gene expression in a spatially resolved manner have resulted in several tour-de-force publicly available datasets, often accompanied by sample-matched dissociated single cell RNA-seq or single cell multi-omic measurements. However, many integrative data analysis tasks for spatial genomics are performed using tools designed with dissociated single cell RNA-seq data in mind, effectively ignoring the specific data structures of spatial genomics data. This project will develop new data science techniques for multiscale data integration of single cell spatial genomics, with applications in several collaborative contexts.

Your key responsibilities will be to:
undertake research in statistical bioinformatics for single cell spatial genomics
publish research papers
demonstrate research excellence
assist with grant writing and publishing original work
participate in research group meetings and other activities
formulate and refine statistical and computational methods for single cell spatial genomics data integration
develop software using the R language and contribute to Bioconductor.


The School of Mathematics and Statistics of the University of Sydney is one of the largest in Australia. It has more than 89 academic staff to supervise research and teaching 74 postgraduate students and 925 equivalent full-time student-load undergraduate students.

About you
The University values courage and creativity; openness and engagement; inclusion and diversity; and respect and integrity. As such, we see the importance of recruiting talent aligned to these values and are looking for a Research Associate who has:

demonstrated ability to conduct research/scholarly activities under limited supervision
the ability and a willingness to collaborate in multidisciplinary teams to contribute to long-term research goals
a strong track record of publishing their research
research strengths in state-of-the-art high dimensional analysis of complex data
superior computer programming or software development skills in R or similar
excellent communication (written and verbal), organisational and problem-solving skills with attention to detail
a high level of interpersonal skills, including the ability to work collaboratively with colleagues
a demonstrated ability to complete work in timely fashion and to write up results for publication
a PhD (or near completion) in bioinformatics, data science, computer science, computational biology or an equivalent combination of training and experience is highly desirable.

To keep our community safe, please be aware of our COVID safety precautions which form our conditions of entry for all staff, students and visitors coming to campus.

Pre-employment checks
Your employment is conditional upon the completion of all role required pre-employment or background checks in terms satisfactory to the University. Similarly, your ongoing employment is conditional upon the satisfactory maintenance of all relevant clearances and background check requirements. If you do not meet these conditions, the University may take any necessary step, including the termination of your employment.

EEO statement
At the University of Sydney, our shared values include diversity and inclusion and we strive to be a place where everyone can thrive. We are committed to creating a University community which reflects the wider community that we serve. We deliver on this commitment through our people and culture programs, as well as key strategies to increase participation and support the careers of Aboriginal and Torres Strait Islander People, women, people living with a disability, people from culturally and linguistically diverse backgrounds, and those who identify as LGBTIQ. We welcome applications from candidates from all backgrounds.

Job website: https://usyd.wd3.myworkdayjobs.com/en-US/USYD_EXTERNAL_CAREER_SITE/job/Research-Associate-in-Statistical-Bioinformatics_0105459-2

Contact name: Simon Drew

Contact email: recruitment.sea@sydney.edu.au

Bioinformatics Research Assistant @ VIC

Position title: Bioinformatics Research Assistant

Employer: WEHI

Closing date: 2023-05-15

Brief position description: An excellent opportunity is available for a Research Assistant in Bioinformatics to join the Advanced Technology and Biology Division at Australia’s pre-eminent biomedical research institute.

The Advanced Genomics Facility forms the nexus for the flow of biological sequence data at WEHI, undertaking a range of sophisticated genomics applications including transcriptomics, functional genomics, single-cell (10x, CEL-Seq2) and spatial (Visium, BGI STOmics, MERSCOPE, and more) analyses run on Illumina, MGI and Nanopore sequencing platforms. We are looking for a graduate research assistant who can contribute to the processing, evaluation and analysis of these data streams

Responsibilities include, but are not limited to:

- Performing data analysis on transcriptomic, single-cell, and spatial data.
- Running/maintaining and developing pipelines for QC and data analysis of genomic, transcriptomic, single-cell and spatial data.
- Communicating QC and analysis results to technical and non-technical researchers.
- Assisting researchers with varying levels of technical expertise to troubleshoot and run their own pipelines.
- Following/implementing best practices for data provenance, management and reproducibility, as well as implementing/testing automations to facilitate these tasks.

Selection Criteria
- Tertiary qualification in bioinformatics/statistics/computer science/software engineering (or other relevant discipline) with an interest in biomedical research. Research experience is advantageous.
- Demonstrable knowledge and experience in R and at least one other programming language (preferably Python). Additional experience with a workflow framework (such as Snakemake, Nextflow or Galaxy) is highly desirable.
- Strong understanding and expertise with the Unix command line. Experience with a computer cluster job-manager (such as SLURM) is desirable. Ability to work independently and in a multi-disciplinary team.
- Effective time management skills and ability to work on several projects in parallel.
- Strong communication skills, written and oral, and an ability to communicate technical concepts to non-technical researchers.

A basic understanding of molecular biology and sequencing is highly desirable.

This position is available for an initial term of 1 year in a full-time or near-full-time capacity. Salary is Research Support Employee Level 5-6 ($73,621-$92,435) subject to experience. Up to 17% superannuation and very attractive salary packaging options are available.

Applications via: https://wehi.wd3.myworkdayjobs.com/WEHI/job/Parkville-Victoria-Australia/Bioinformatics-Research-Assistant_JR1816-1

Job website: http://www.wehi.wd3.myworkdayjobs.com/WEHI/job/Parkville-Victoria-Australia/Bioinformatics-Research-Assistant_JR1816-1

Contact name: Peter Hickey

Contact email: hickey@wehi.edu.au

Postdoctoral scholar @ Pennsylvania State University

Position title: Postdoctoral scholar

Employer: Pennsylvania State University

Closing date: 12/31/2023

Brief position description: JOB DESCRIPTION AND POSITION REQUIREMENTS:

The Uzun Laboratory at the Penn State College of Medicine, Department of Pediatrics, Hershey, PA, is seeking a postdoctoral scholar in computational biology. Responsibilities for this position include data analysis, method development, scholarly activities and other related tasks.

Apply at: https://psu.wd1.myworkdayjobs.com/en-US/PSU_Academic/details/Postdoctoral-Scholar---Computational-Biology_REQ_0000039061 

Responsibilities:

1) Biomedical data analysis (40%): Statistical analysis of biomedical data by using existing methods and developing custom code scripts.

2) Bioinformatics method development (40%): Developing Bioinformatics frameworks using computational and statistical approaches for the problems that are not addressed adequately in the Biomedical domain.

3) Scholarly activities (10%): Generating academic outputs, such as presentations, grants, and manuscripts.

4) Related tasks (10%): Other related tasks assigned by the principal investigator.

Eligibility:

Candidates holding a PhD degree in Computer Science, Math, Statistics (in hand at time of hire) or a related field are eligible to apply. Life sciences (Biology, Genetics, Biochemistry, etc.) PhDs with computational experience are also eligible for this position. Bioinformatics experience is preferred but not required. International scholars and members of underrepresented groups are encouraged to apply. PhD candidates who submitted their doctoral thesis and expecting to graduate no later than 2023 Summer, can also apply.

Requirements: 

Prior hands-on experience in R and Unix/Linux shell scripting is required with demonstration in past projects.

Application process:

The candidates are required to submit their electronic applications via PSU Career Portal. The following documents are required for the application to be processed:

1) Cover Letter (1 page): Must contain a brief description of background, career goals and how they are related with this position.

2) Reference List (1 page): Must contain information for at least 3 references. For each reference, the following information is to be provided: Name, title, institute, department, email address, phone number, relationship (advisor, co-advisor, collaborator, etc.). Should include the PhD advisor as one reference. If that’s not possible, a short explanation must be provided for stating the reason (retirement, inaccessibility, etc.) for the exclusion, in this document.

3) CV (4 pages maximum): Must contain at least contact information, education, experience, publication list and skills.

4) Statement of Purpose (3 pages maximum): A detailed description of research and educational background, research interests and intentions and career plan. Must be composed of three sections :

4.1) Background: Expertise and skills gained.

4.2) Research Interests: Research intentions and goals for the postdoctoral role and afterwards.

4.3) Career Plan: Career goals and 5-year career plan. 

IMPORTANT NOTICE: In order for the applications to be processed, all 4 documents MUST be uploaded during the application. The applications with missing documents will be discarded and NOT be considered for the position. If you have any questions or issues with the application process, please contact the Principal Investigator directly: yuzun at pennstatehealth psu edu. 

This is a limited-term non-tenure line position funded for one year from date of hire, with possibility of refunding. 

Employment will require successful completion of background check(s) in accordance with University polices. 

The Pennsylvania State University is committed to and accountable for advancing diversity, equity, and inclusion in all of its forms. We embrace individual uniqueness, foster a culture of inclusive excellence that supports both broad and specific diversity initiatives, leverage the educational and institutional benefits of diversity, and engage all individuals to help them thrive. We value inclusive excellence as a core strength and an essential element of our public service mission. 

Job website: http://psu.wd1.myworkdayjobs.com/en-US/PSU_Academic/details/Postdoctoral-Scholar---Computational-Biology_REQ_0000039061

Contact name: Yasin Uzun

Post Doctoral Researcher @ VIC

Position title: Post Doctoral Researcher - Molecular Biomarkers and Translational Genomics Laboratory

Employer: Peter MacCallum Cancer Centre

Closing date: 24th April 2023

Brief position description: Applications are invited to join an exciting research program within the Molecular Biomarkers and Translational Genomics Laboratory led by Sarah-Jane Dawson at the Peter MacCallum Cancer Centre (https://www.thedawsonlab.com/). The research will explore the use of circulating tumour DNA to study genomic and transcriptional evolution and provide insights into treatment response and resistance in cancer.

The position will involve the analysis of large-scale genomic data, with a focus on whole genome sequencing, through the application of best-practice bioinformatics workflows and the development of innovative new methods as required. Applicants should have demonstrated experience developing and maintaining bioinformatics analysis workflows. Experience working with cloud computing, containers and version-controlled pipelines is desirable but not required.

The position will require a highly motivated and skilled bioinformatician or computational biologist with expertise in the analysis of next generation sequencing data, integration of genome-wide datasets, competency in programming languages R and/or Python/Perl and experience with working on a high-performance computing cluster. The individual will be responsible for driving their own specified projects, but will also collaborate very closely with cancer molecular biologists to work on joint initiatives.

The position will be in a research environment that includes a large and interactive group of bioinformaticians and computational biologists in the Computational Cancer Biology Program and the Bioinformatics Core Facility. The position will be initially for a fixed term of 12 months with the opportunity to extend. Remuneration will be commensurate with qualifications and experience.

Essential Requirements
PhD in Computational Biology, Bioinformatics or similar
Experience in analysing a wide range of next generation sequencing data including whole genome, targeted sequencing and/or RNA sequencing.
Demonstrated capacity for independent research and supervision
Demonstrated experience developing and maintaining bioinformatics analysis workflows
Willingness to learn new techniques
Ability to work both independently and as part of a team
High level organisational, interpersonal and time management skills
First author publications in a relevant area
Excellent Python or R programming skills
Experience with high performance computing clusters environments

Desirable Requirements
Expertise in cancer research
Experience working with cloud computing, containers and version-controlled pipelines

Applicants to this role should provide a covering letter outlining relative key skills and experience to assist us with our assessment.

Job website: http://careers.petermac.org/job/MELBOURNE-Post-Doctoral-Researcher-Molecular-Biomarkers-and-Translational-Genomics-Laboratory-VIC-3000/932665510/

Contact name: Dineika Chandrananda

Contact email: Dineika.Chandrananda@petermac.org

Field Application Scientist @ Australia

Position title: Field Application Scientist

Employer: Oxford Nanopore Technologies

Closing date: 26/04/2023

Brief position description: We are looking for highly motivated and driven individual to join the Technical Services team, as a Field Applications Scientist covering Australia, New Zealand, and South East Asia. Ideally this role is to be based on the Eastern Seaboard of Australia. In this role you will assist customers in experimental design, product installation, use of wet and dry lab products, pipeline development, data analysis, and workflow implementation and validation, in collaboration with other internal and customer-facing teams! Specifically this role will be to support and train our growing customer base to implement new and novel bioinformatic tools designed for long read sequencing in areas such as methylation, structural variant analysis, gene fusion, long read metagenomics assembly, de novo assembly, RNA Isoform detection etc...

Job website: https://ejnh.fa.em2.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1/requisitions/preview/1836

Contact name: Michael Yarski

Contact email: michael.yarski@nanoporetech.com

Research Fellow in Computational Sciences for Infectious Diseases @ VIC

Position title: Research Fellow in Computational Sciences for Infectious Diseases

Employer: University of Melbourne

Closing date: 21 April 2023

Brief position description: We are seeking a highly motivated Research Fellow to join Prof. Matthew McKay and Dr. Syed Faraz Ahmed to assist with research projects related to following grants:

- NHMRC Ideas Grant, Using Big Data to Engineer Highly Immunogenic Hepatitis C Virus Envelopes for the Induction of Broad Neutralising Antibodies
- ARC Discovery Grant, Engineering Methods for Resolving Complex Mutational Networks in Proteins

The first project looks at using data science methods to rationally design vaccines for HCV and the second project looks at developing computational platforms to understand the complex mutational patterns that underpin virus protein evolution. 

The appointee will be a member of a team focused on employing computational approaches/machine learning/data science to understand viral infectious diseases, their evolution, and to design next-generation vaccines and therapies. The team is computationally focused and works with experimental virologists and immunologists in the Peter Doherty Institute for Infection and Immunity (where Prof McKay is jointly appointed in the Department of Microbiology and Immunology), as well as with other national and international collaborators. Recent scientific contributions of the group include guiding the development of commercial COVID-19 vaccines and commercial products for measuring human immune responses.

The appointee will contribute to a program involving the development of computational models and bioinformatics platforms to identify immune targets for viral pathogens including Hepatitis C virus, SARS-CoV-2, and future pandemic threats. The platforms will be used to design vaccine strategies for eliciting targeted T cell responses and/or inducing broadly neutralizing antibodies. The successful candidate will work under the direction of Prof McKay and Dr Syed Faraz Ahmed and will work closely with computational and experimental collaborators.

Responsibilities include:

Independently planning and carrying out research on the nominated research project and working towards completion of the aims of the project

Be responsible for qualitative and statistical analysis of research data

Identifying sources of funding to support individual or collaborative projects, relating to teaching, research and engagement practice in the discipline

Contributing to teaching, training, scientific mentoring and supervision of students

- A PhD, or near completion of PhD, in electrical engineering or computer science, or in other relevant technical fields including computational biology, bioinformatics, biophysics, statistics, mathematics, genetics 

- A record of quality research in relevant fields, as evidenced by publications in leading journals and at conferences commensurate with opportunity

- Demonstrated experience with one or more high-level programming languages, e.g., Python, R, Matlab

- Demonstrated capacity to communicate research concepts to technical and non-technical audiences

Job website: https://jobs.unimelb.edu.au/caw/en/job/912133/research-fellow-in-computational-sciences-for-infectious-diseases

Contact name: Matthew McKay

Bioinformatician - Cancer Research @ VIC

Position title: Bioinformatician - Cancer Research

Employer: Peter MacCallum Cancer Centre

Closing date: 5 April 2023

Brief position description

This position will primarily support the analysis of single-cell RNA sequencing data at Peter Mac Research. Prior experience in single-cell data analysis is essential. This position will work and communicate closely with a team of cell biologists and bioinformaticians to address the analytical challenges posed by evolving genomic technologies.

Responsibilities
* Analyse single-cell RNA seq and other next generation sequencing data using best-practice methods and pipelines
Be exposed to cutting-edge research techniques in cancer therapeutics and contribute to solving related bioinformatics problems
* Develop pipelines and support data processing
* Apply computational and statistical methods to answer research questions
* Communicate work progress and results to researchers frequently

Qualifications
* A Master or higher degree in Mathematics/Statistics/Bioinformatics or equivalent, with outstanding academic results in final year subjects
* At least two years of experience in the analysis of next-generation sequencing data for human disease research
* At least one year of experience in single-cell RNA-seq data analysis
* Highly developed R and Python programming skills
* Experience working in a Unix environment and shell scripting
* Excellent verbal and written communication skills
* Strong interests in cancer research
* Proven ability to manage time effectively and be reliable and approachable

Job website: http://www.seek.com.au/job/66338853

Contact name: Jason Li

Contact email: jason.li@petermac.org

Bioinformatics Officer @ SA

Position title: Bioinformatics Officer

Employer: SA Genomics Centre (SAGC) / South Australian Health & Medical Research Institute (SAHMRI)

Closing date: Until filled

Brief position description: The South Australian Genomics Centre (SAGC) is a multi-institutional, national genomics and bioinformatics facility that is supported by Bioplatforms Australia (BPA) through the Australian Government’s National Collaborative Research Infrastructure Strategy (NCRIS). The SAGC has consolidated genomics and bioinformatics expertise in the state, with a group of ~10 genomics and bioinformatics staff working side-by-side to deliver innovative genomics and bioinformatics solutions across all areas of genomics research, including agriculture, healthcare and ecology

This is an exciting opportunity for a post-doctoral researcher or experienced MSc-level bioinformatician to join the SAGC bioinformatics team. To flourish in this role, you will need to be able to work across multiple different projects and to possess excellent organisational and time-management skills.

This role is primarily responsible for supporting SAGC users to appropriately design genomics-related projects and to analyse and interpret their data. Working collaboratively with researchers across different disciplines, you will have a varied and interesting workload across projects in different areas of genomics, leading bioinformatics analyses with varying levels of complexity. 

There are significant opportunities for professional growth and development through exposure to data sets from different genomics technologies including single cell and spatial transcriptomics. Staff are expected to enable research by leading the development of reproducible, standardised pipelines for genomics data analysis and, where necessary, develop new methods and pipelines. Your career development will be supported and you will be encouraged to publish your research and to collaborate on major funding applications to national and international funding bodies. 

You will also be supported to develop your bioinformatics capabilities; ensuring that the SAGC can remain at the forefront of genomics. It is expected that you will have interest in and develop your capabilities in at least one specialist area of bioinformatics.

About the Role
Key responsibilities include:
• Support researchers to design innovative but rigorous genomics projects and collaboratively support the bioinformatics aspects of these projects. 
• Develop and maintain reproducible bioinformatics pipelines and analyses approaches for routine analyses. 
• Where needed develop and implement new bioinformatics approaches, methods or data visualisation approaches. 
• Contribute to/or lead the drafting of reports and publications. 
• Contribute to/or lead the drafting of applications to major funding bodies.

About You
The successful candidate will possess the following key attributes:
• MSc, PhD, or equivalent experience, in either bioinformatics, computer science, physics, statistics or other relevant discipline
• Have a broad understanding of at least two of the following areas and a significant interest in developing a deep understanding in at least one:
o Transcriptomics: bulk RNAseq, scRNAseq, spatial transcriptomics, 
o Genomics: variant, haplotype and diversity analysis, genome assembly, metagenomics, epigenetics
o DevOps: version control: test driven development and continuous integration, containerisation using Docker/Singularity
o Systems biology: multi-omics data integration, network analysis
o Statistics: linear models, ANOVA, hypothesis testing
o Visualisation: data visualisation and User Interface/Experience design
o Workflow systems: Snakemake and/or Nextflow
o Other Omic's technology: metabolomics, proteomics
• Prior experience with at least one of the following scripting languages: bash, R, Python and Perl
• Minimum 2 years relevant work experience

Please see the website below for more information, position description and application process.

Job website: https://sahmri.org.au/careers-and-study/working-at-sahmri/vacancies/bioinformatics-officer-2

Contact name: Sen Wang

Contact email: Sen.Wang@sahmri.com

Postdoctoral position/Research Assistant @ NSW

Position title: Postdoctoral position/Research Assistant

Employer: Wong Lab, Victor Chang Cardiac Research Institute

Closing date: Until filled

Brief position description: Your next career opportunity
The Wong Lab is seeking a driven and motivated computational Postdoctoral Fellow to join the Regulatory Systems Laboratory at the Victor Chang Cardiac Research Institute. Our main goal is to understand gene regulatory control, in the context of evolution, development, in health and aging, using comparative methods, novel technologies and animal models. Our lab has capability in computational and experimental methods.

In this role you will have the opportunity to study the genetic and molecular mechanisms underpinning regulatory element function using high-throughput data and other impactful projects. You will receive support from a collaborative inter-disciplinary team of scientists in molecular biology, computer science, and genomics.

Does this sound like you?
​PhD in computational biology, genomics, computer science or a related discipline
Passion for biology in particular gene regulation / genome biology / epigenetics
Extensive experience with R/Python/HPC usage
Excellent biostatistics skills
Excellent written communication skills and the ability to communicate and critically interpret results

Job website: http://www.victorchang.edu.au/careers/jobs-available

Contact name: Emily Wong

Contact email: e.wong@victorchang.edu.au

Group Leader - Computational Biology @ VIC

Position title: GROUP LEADER – COMPUTATIONAL BIOLOGY

Employer: Peter MacCallum Cancer Centre

Closing date: 1 June 2023

Brief position description: We are recruiting up to two Group Leaders to increase the capacity and efficiency of our “discovery to translation” cancer research pipeline. We have a specific focus on building and expanding our Computational Biology Program that uses mathematics, statistics and computing to generate new discoveries in cancer. There are strong synergies between researchers in this program and the other research programs at Peter Mac that provide a breadth of collaborative opportunities for the new appointee. The Group Leader will develop and lead a team conducting internationally significant and innovative research to enhance our understanding of cancer development from fundamental biological principles of cancer to progression, evolution and translation into clinical practice.

The Group Leader is responsible for ensuring that their group’s financial and operational processes are sustainable and in accordance with regulatory, commercial and ethical obligations. They will be driven to achieve excellence in research outputs, mentorship and make a significant contribution to the local, national and international scientific communities.

Appointments will be considered at the level of new group leader (Level C) through to experienced Associate Professor (Level D).

Job website: http://careers.petermac.org/job/MELBOURNE-Group-Leader-VIC-3000/937192610/

Contact name: Alicia Oshlack

Contact email: Alicia.Oshlack@petermac.org