Position title: Bioinformatician – Human Gut Microbiome Metabolism
Employer: Microba Life Sciences
Closing date: Open until filled
Brief position description: We are seeking an enthusiastic, talented and experienced computational biologist / bioinformatician of gut microbiome metabolism. Microba currently has a globally unique data set consisting of over 10,000 proprietary metagenomes, over 1 million high quality microbial genome sequences, and a large biobank of microbial isolates. In this role, you will build world-class bioinformatic applications and methodologies that describe the natural metabolic functions of these organisms and gut microbial ecology at scale. You will also assist in the interpretation of these results for internal and external stakeholders and in primary research activities to determine how interventional modulation of the microbiome can improve metabolic function of the gut microbiome. This is a senior role and would suit a biologist with applied bioinformatics skills or an experienced bioinformatician with a demonstrated track record in metabolism related research and tool development.
There are opportunities for publications, conference attendance and the production of white papers. This is a rare opportunity to apply your scientific expertise and skills to an innovative platform making a real impact on health and well being.
Key activities/duties
- Build annotation pipelines using Hidden Markov Models (HMMs) and other appropriate methods to functionally annotate gene sequences
- Determine through direct interrogation and/or validated imputation the core and secondary metabolic functions of genomes and species by reconstructing annotated pathways in-silico
- Quantification of community gene and pathway encoded potential in-vivo through development and application of appropriate bioinformatics and statistical methods
- Validate methods with targeted in-silico and in-vitro experiments.
- Interpret functional data for meaningful knowledge acquisition
- Assist internal teams for Research, Platform and Consumer products in communication of metabolic and functional information to clients
- Communicate results to external research and corporate clients as required
- Assist the Science Team to author in depth reports for corporate clients about functional outputs and experiment relevant functional signals
Job website: http://www.linkedin.com/jobs/view/2722248452/
Contact name: David Wood
Contact email: david.wood@microba.com