Research Officer, Bioinformation @ VIC

Position title: Research Officer, Bioinformation

Employer: University of Melbourne

Closing date: 04 Aug 2023

Brief position description: This is an exciting opportunity for a highly motivated Research Officer to join the research group of Professor Lachlan Coin at The Peter Doherty Institute for Immunity and Infection. As part of the NHMRC-funded project NITRIC, you will have the unique opportunity to contribute to the largest pediatric cardiac surgical intervention trial worldwide. By implementing cutting-edge genomic analyses and machine learning approaches, you will play a crucial role in identifying gene expression patterns associated with patient outcomes in congenital heart disease. Join our collaborative team and make a significant impact in the field of computational biology and bioinformatics, while developing your own independent program of research and contributing to leading specialist journals.

Job website: http://jobs.unimelb.edu.au/en/job/913455/research-officer-bioinformation

Contact name: Lachlan Coin

Contact email: lachlan.coin@unimelb.edu.au

Domain Bioinformatician (Research Officer) @ VIC

Position title: Domain Bioinformatician (Research Officer)

Employer: Baker Heart and Diabetes Institute

Closing date: 15/07/2023

Brief position description: This is a position for a Research Officer eager to provide their biostatistics expertise for experimental and study design, data analyses and interpretation at the Institute, and perform high quality research in bioinformatics, genomics or computational biology. Half of the effort will be supporting other labs in Baker, and the other half will be independent research. Since many collaborations involve biobank data analysis, a basic understanding of epidemiology is desirable. We are particularly interested in candidates with experience and a strong interest in single-cell analysis.

Job website: http://www.seek.com.au/job/68128798

Contact name: Fumihiko Takeuchi

Contact email: Fumihiko.Takeuchi@baker.edu.au

Bioinformatics Research Officer / Senior Research Officer @ VIC

Position title: Bioinformatics Research Officer / Senior Research Officer

Employer: WEHI

Closing date: 07/07/2023

Brief position description: An excellent opportunity is available for a Bioinformatics Research Officer / Senior Research Officer to work on spatial omics as part of the Advanced Technology and Biology Division and Bioinformatics Division (Phipson Lab) at Australia’s pre-eminent biomedical research institute. 

WEHI is building on its reputation for excellence in advanced technologies with the development of a nationally leading centre for spatial omics and the acquisition of multiple new technologies in a highly collaborative and open framework. 
In conjunction with the Bioinformatics Division and many scientific collaborators, the Advanced Genomics Facility at WEHI comes to grips with data from many cutting-edge technologies, and ground-breaking projects, every day. 
In this role, you will share in the analysis of data from experiments in single-cell and spatial omics, applying rigorous principles and using the latest computational and statistical approaches. 
You will combine contributions to many diverse projects, taking on experimental design, trouble-shooting and data evaluation in a close partnership with our laboratory team, with a more prominent role in developing methodologies or the detailed analysis of selected key projects. 
The role is pivotal in building closer links between technology and analytical streams at WEHI and designed to suit someone keen to work in one of the most dynamic areas of bioscience, looking either to build on a recent PhD by gaining a lot of experience quickly (RO) or who has substantial existing experience in computational data analysis but may wish to enter a new and dynamic field (SRO). 
This post could lead to either fully research-driven or staff-scientist career pathways. 

Responsibilities include, but are not limited to: 

- Data analysis on a variety of fast-developing spatial omics technologies available at WEHI including 10x Visium, 10x Xenium, BGI STOmics, and Vizgen MERSCOPE. 
- Leveraging and integrating the analysis of spatial omics data from different platforms and with other omics data types (e.g., single-cell RNA-sequencing). 
- Collaborative analyses with wet-lab and clinical researchers. 
- Communicating analysis results and methodologies to technical and non-technical researchers. 
- Developing statistical and computational methods to enable these analyses. 
- Benchmarking of technologies and analysis methods to develop technology recommendations and best-practice data analysis workflows. 

Selection Criteria 
- PhD or equivalent in statistics/bioinformatics (or other relevant disciplines) with a strong interest in biological research. Research experience is advantageous. 
- Demonstratable knowledge and experience in a data analysis programming language (e.g., R, Python). 
- Ability to work independently and in a multi-disciplinary team. 
- Effective time management skills and ability to work on several projects in parallel. 
- Strong communication skills, written and oral, and an ability to communicate technical concepts to non-technical researchers. 
- A basic understanding of molecular biology and sequencing is highly desirable. 

This position is available for an initial period of 2 years in a full-time or near-full-time capacity. Salary is RO/SRO ($105,555-$125,339).

Job website: http://wehi.wd3.myworkdayjobs.com/en-US/WEHI/details/Bioinformatics-Research-Officer---Senior-Research-Officer_JR1916-3

Contact name: Peter Hickey

Contact email: hickey@wehi.edu.au

Bioinformatician @ QLD

Position title: Bioinformatician

Employer: QIMR Berghofer Medical Research Institute

Closing date: 12 June 2023

Brief position description: The Molecular Oncology team uses bioinformatic and machine learning approaches to analyse cancer molecular profiling data, including genomic, transcriptomic and DNA methylation data, to link it with treatment responses and patient outcomes. The research spans multiple solid cancer types, including ovarian, endometrial and lung cancers.

Role Purpose / Responsibilities
Applications are invited for a bioinformatician to join the Molecular Oncology team led by Olga Kondrashova. The exciting position involves analysis of a variety of next-generation sequencing data using existing and newly developed pipelines in lung, endometrial and ovarian cancers. The research is centred around linking tumour molecular profiles with patient treatment responses, improving understanding of drug resistance and identification of novel treatment strategies through analysis of pre-clinical models. The role involves utilising and developing bioinformatic approaches to analyse data, such as whole-exome and whole-genome sequencing, RNA-sequencing and CRISPR screen sequencing. This position will involve working independently and alongside other bioinformaticians in the Molecular Oncology and collaborators. 

The following duties will apply:
•Bioinformatic analysis of next-generation sequencing data
•Research and implementation of appropriate analysis methodology
•Development of custom analysis pipelines
•Presentation of results in internal and external meetings
•Contribution to scientific publications
•Ensure work practices comply with the requirements of the Work Health and Safety Act, related legislative requirements and the Institute's WH&S policies and procedures. 

About you
The role calls for an experienced and enthusiastic bioinformatician with the following skills:
•Masters or PhD in computational biology/bioinformatics with demonstrated experience
•Experience in genomics and next-generation sequencing data analysis
•Strong experience using the Linux/Unix Operating System
•Proficiency in R and/or Python
•Willingness and ability to learn new technical skills
•Ability to work independently
•Interest in cancer research and a desire to further a career in science
•Experience in machine learning is beneficial

Remuneration: Salary range is $82,369 to $95,329 p.a. depending on experience, plus super and salary packaging. This is a two-year, full-time appointment with possible extension.

Job website: https://www.seek.com.au/job/67631404

Contact name: Olga Kondrashova

Contact email: olga.kondrashova@qimrberghofer.edu.au

Statistical geneticist / Bioinformatician

Position title: Statistical geneticist / Bioinformatician

Employer: Seonix Bio

Closing date: 30/6/2023

Brief position description: Seonix Bio is a fast growing clinical genetics company developing polygenic risk score products and services, initially for eye health. Our first offering is a polygenic risk score for glaucoma that helps clinicians save sight by enabling earlier diagnosis and treatment of those at risk. This will be launched as a clinical service in 2023. Our technology is based on world leading research, published in Nature Genetics, and the company is at the cutting edge of polygenic risk score development. 

We are seeking a talented statistical geneticist / bioinformatician to:
• Develop and implement polygenic risk scores and other algorithms for a variety of clinical applications, including methodological development
• Develop statistical models and methods that incorporate both genetic and non-genetic data to improve risk prediction
• Analyse and interpret complex clinical study data, including interfacing with our research partners

The role will be tailored according to experience of the candidate.

The successful candidate will report to the CEO and will work with our Scientific Advisory and software teams. Our leadership team has a track record of building genetics businesses that change clinical care globally, and our Scientific Advisory team is composed of leading academics and clinicians in the area. 

We are involved in a number of research projects with collaborators, and there will be opportunities to participate in publications.

The role is full-time, though part-time could be possible for the right candidate. A minimum of 3 days per week is required. 

We will offer a competitive package, depending on experience. Remote work is possible for the right candidate.

The successful candidate will play a key role in a small team of committed, talented and friendly people. This is a rare opportunity to join an exciting startup company and make a real impact. 

REQUIREMENTS
• Ph.D. in a relevant discipline (including a Ph.D. student shortly to submit)
• Strong statistical genetics / bioinformatics skillset
• Strong programming skills, typically with experience of R at a minimum
• Experience in/knowledge of polygenic risk scores, ideally including development and use of associated scores and pipelines, and statistical analysis of data
• Strong written and verbal communication skills
• Ability to work independently and in a multi-disciplinary team
• Ideally, experience of Nextflow workflow and/or SLURM scheduling
• Ideally, experience with containers and working in the cloud
• Ideally, experience of machine learning/AI algorithms

Job website: https://www.seonixbio.com/careers/

Contact name: Nick Haan

Contact email: careers@seonixbio.com

Research Officer/Post-doctoral Scientist – Bioinformatics Stem Cell Biology @ NSW

Position title: Research Officer/Post-doctoral Scientist – Bioinformatics Stem Cell Biology

Employer: Children's Medical Research Institute, University of Sydney

Closing date: 09 June 2023

Brief position description: About the job
Children’s Medical Research Institute (CMRI) was Australia’s first dedicated paediatric research facility and is now one of the nation’s most highly regarded independent medical research centres. Our research focuses on embryonic development, cancer, neuroscience and gene therapy and we have a strong international reputation based on our research outcomes. CMRI’s research programs are supported by state of the art facilities and committed research and support staff. Our achievements are made possible by a loyal network of community supporters, highly engaged donors and the very successful Jeans for Genes® fundraising campaign.

A two-year Research Officer/Post-doctoral position funded by a Medical Research Future Fund (MRFF) Stem Cell Therapies Mission grant is now available at the Computational Systems Biology lab at CMRI. We are looking for a highly motivated researcher to employ computational and data analytics approaches to investigate cell identity and cell fate decisions using bulk and single-cell multi-omics and spatial transcriptomics data generated from stem cells and organoids systems. The successful applicant will have a PhD (or be in the final stages of completion) with a strong background in data analytics and computational systems biology, and a working knowledge in molecular cell and stem cell biology.

Position Summary
The Computational Systems Biology (CSB) lab at CMRI is welcoming applications for a Research Officer/Post-doctoral Scientist to conduct research in the broad area of computational systems biology of stem cells and organoid systems. Our research focuses on the acquisition of particular cell identity and cell fate decisions during cell differentiation, and to translate such knowledge for stem cell engineering and regenerative medicine. In collaboration with the Stem Cell Medicine lab at CMRI, the CSB lab has established experimental techniques including single-cell multi-omics and spatial transcriptomics, and mass spectrometry-based proteomics and phosphoproteomics to profile human and mouse embryonic/adult stem cells and various stem cell-derived organoids (e.g., eye organoids, brain organoids, and heart organoids). This appointment is at CMRI and will be affiliated with the Faculty of Medicine and Health at The University of Sydney. The appointee is expected to lead their own projects, contribute to internal or external collaborations, and when possible guide student research. The ability to work as part of a team is essential.

Position Compensation
Duration: Initially 2-year fixed term with potential for an 1-year extension (full time).
The candidate will be compensated with a competitive remuneration package in accordance with qualifications and experience. Additional benefits include the provision of a Public Benevolent Institution salary packaging scheme and participation in an employer-contributed superannuation fund.

Essential Characteristics
The appointee will be an ambitious post-doctoral scientist with a bold and creative approach to research. They will be capable of independent thought and project design, and will be able to work in a collaborative team setting. Exceptional candidates will be eligible for an internal CMRI post-doctoral fellowship, and the possibilities provided by this unique funding opportunity. The following characteristics and research experience are essential to this position.

• A PhD in computational biology, bioinformatics, applied statistics, computer science, systems biology and molecular biology or another closely related scientific discipline. Candidates in the final stages of PhD submission are welcome to apply.
• High proficiency with at least one programming language (e.g., R, Python).
• Demonstrated experience with data analytics in omics data analysis.
• Proven ability and commitment to produce high quality work, including track record of scientific publication.
• Proven research ability, and evidence of self-motivation and research potential.
• Proven excellence in written and oral communications, interacting with a variety of researchers and stakeholders.

Desirable Characteristics
• Knowledge of stem cells and molecular cell biology.
• Experience with deep learning.

Computational Systems Biology Lab
The CSB lab (https://smex-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fpyanglab.github.io&umid=4e18582d-3f3e-417b-8f53-15c6fe845f01&auth=2af5473c4b03509246eb08bd803a6cf835f69953-d29bb5b92a435ca262ffa6b231098c9ef9d42797) combines computational (‘dry’) and experimental (‘wet’) expertise to study cell identity and cell fate decisions of stem cells and organoids systems. The lab resides in CMRI, Westmead, while also holding office space both at the School of Mathematics and Statistics, and the Charles Perkins Centre, The University of Sydney. The CSB lab collaborates closely with other lab at CMRI (e.g., Stem Cell Medicine, Embryology) and is part of the Sydney Precision Bioinformatics Alliance and Sydney Precision Data Science Centre, The University of Sydney. The appointee will have ample opportunity to collaborate with bioinformaticians, statisticians, computational and systems biologists, and stem cells and developmental biologists within CMRI and from The University of Sydney.

Current focus of the CSB lab is on using computational approaches and bulk and single-cell multi-omics data to characterise cell identity and predict cell fate decisions for stem cell differentiation and organoid generation. The lab is currently supported by an NHMRC Investigator grant and two MRFF Stem Cell Therapies Mission grants. Most significant publications of the lab in the last five years appears in Cell Press and Nature Portfolio (http://pyanglab.github.io/publications.html) For more information please visit https://pyanglab.github.io/.

Application
Applications should include a cover letter (citing PV2250), curriculum vitae and contact details (phone/email) of three professional referees and be forwarded to recruitment@cmri.org.au

Closing date for applications is (09 June 2023).

Please direct enquiries regarding the position to Associate Professor Pengyi Yang, NHMRC Investigator, pengyi.yang@sydney.edu.au.

Job website: http://pyanglab.github.io/

Contact name: Pengyi Yang

Contact email: pengyi.yang@sydney.edu.au

Bioinformatics Postdoc Level A or B (3+ years) @ QLD

Position title: Bioinformatics Postdoc Level A or B (3+ years)

Employer: James Cook University (Cairns)

Closing date: June 6th

Brief position description: Bioinformatics postdoc / Contract until Dec 2026 / Level A or B 

Come enjoy the lifestyle in tropical Cairns!

Looking for a technically strong bioinformatician to develop software/workflows in support of several large genomics projects. The bioinformatician will focus on workflows aimed at understanding the role of genetic variation in applications such as human disease or population genetics. Technologies employed include short and long read sequencing as well as single cell technologies such as 10X and MissionBio Tapestri.

Job website: https://myhronline.jcu.edu.au/ords/hrprodords/WK8127$VAC.QueryView?P_VACANCY_REF_NO=18418

Contact name: Matt Field

Contact email: matt.field@jcu.edu.au

PhD Project - Clinical Proteomics for Paediatric Cancer @ NSW

Position title: PhD Project - Clinical Proteomics for Paediatric Cancer

Employer: Children’s Medical Research Institute

Closing date: Open until filled

Brief position description: Background: Paediatric cancer remains the largest cause of death from disease in Australian children. Survivors suffer significant long-term treatment toxicity and poor quality of life. Precision medicine involves generating molecular data that is unique to an individual, to identify features called biomarkers that can inform treatment decisions. Proteomics is the study of the complete set of proteins in a cell. Proteins are highly attractive targets as potential biomarkers, as most anticancer drugs interact directly with proteins rather than DNA or RNA. Mass spectrometry is a technology that can measure an entire proteome, quantifying tens of thousands of proteins in a single cancer sample and therefore including a wealth of potential novel cancer biomarkers.

Project aim: This project will form a major stream in a program of research to investigate how proteomics can improve biomarker discovery in paediatric cancer. We will use mass spectrometry to generate protein measurements from Australian cohorts of paediatric cancers and apply bioinformatics expertise to define a computational signature to improve prediction of treatment response. The research will be highly translational, aiming to explore clinically relevant research questions in paediatric cancer to address urgent areas of unmet need.

PhD Candidate requirements: A background in biology or oncology will be highly advantageous. In this project you will learn computational biology in cancer research. While previous coding experience will be highly valuable, it is not essential because you can gain these skills during your PhD. You will receive excellent training in all aspects of research, including reading scientific literature, conducting high-quality and reproducible research, peer-reviewed publishing and presenting at scientific conferences. The successful PhD Candidate will be highly motivated, a quick learner, strong communicator and eager to pursue a career in cancer science.

About the supervisors: Your PhD will be jointly supervised by Drs Rebecca Poulos and Bhavna Padhye, who are inaugural Sydney Cancer Partners Translational Partners Fellows. Dr Poulos is a Senior Research Officer at the Children’s Medical Research Institute (CMRI). She is a cancer biologist, bioinformatician and expert in multi-omic data integration. She has published as a first-author in high-impact journals including Nature and Cancer Cell, received several prestigious research awards, and has won over $1.25 million in research funding as a Chief Investigator. Dr Padhye is a paediatric oncologist staff specialist at Children’s Hospital Westmead (CHW). She is also clinical lead in the Molecular Genomics team at the Children’s Cancer Research Unit (CHW), site Principal Investigator for the Children’s Oncology Group and member of ANZCHOG, a national clinical trials group for childhood cancer. 

Research environment: You will join the Children’s Medical Research Institute (CMRI), which is home to the ProCan research initiative. ProCan (ie, the Australian Cancer Research Foundation International Centre for the Proteome of Human Cancer) is a world-first program, conducting large-scale proteomic research to change the way cancer is diagnosed and treated. You will join the Cancer Data Science group in ProCan, a research team comprising several highly skilled computational biologists, statisticians, AI experts and data scientists. During your PhD, you will also liaise with a range of multi-disciplinary experts in ProCan, and with clinician researchers at the Children’s Hospital Westmead (CHW). Both CMRI and CHW are located in the world class Westmead Health Precinct.

Job website: http://www.sydney.edu.au/research/opportunities/3266.html

Contact name: Rebecca Poulos

Contact email: rpoulos@cmri.org.au

Computational biologist / Bioinformatician / Data scientist @ NSW

Position title: Computational biologist / Bioinformatician / Data scientist

Employer: Children’s Medical Research Institute

Closing date: Monday 5th June 2023

Brief position description: Position description: Our research team is seeking a computational biologist (or bioinformatician or data scientist) to join an exciting new translational research project studying the proteomics of childhood cancer. This project will be led by Dr Rebecca Poulos (ProCan, CMRI) and Dr Bhavna Padhye (paediatric oncologist staff specialist at Children’s Hospital Westmead). Daily work activities will involve reading scientific literature, data processing and quality control, data analysis (statistical and visualisation) and writing research manuscripts. This is a full-time role, but applicants requesting a part time position will be considered. Flexible work arrangements will be possible. 

Work environment: You will join the Children’s Medical Research Institute (CMRI), an independent medical research organisation with a strong international reputation for research excellence in fields including cancer, genetic diseases, embryology and proteomics. CMRI is home to the ProCan research initiative, which is the Australian Cancer Research Foundation International Centre for the Proteome of Human Cancer. ProCan is a world-first program, conducting large-scale proteomic research to change the way cancer is diagnosed and treated. If successful, you will join the Cancer Data Science group in ProCan, a research team comprising several highly skilled computational biologists, statisticians, AI experts and data scientists. In this role, you will also liaise with a range of multi-disciplinary experts in ProCan, and with clinician researchers at the Children’s Hospital Westmead (CHW). Both CMRI and CHW are located in the world class Westmead Health Precinct.

Requirements: 
• Experience working in or studying computational biology, bioinformatics or data science. 
• Moderate levels of coding skill, with expertise using Python and/or R preferable.
• Evidence of experience conducting and publishing peer reviewed scientific research.
• Biology, proteomics or medical research experience will be highly regarded but not essential.
• A PhD is highly advantageous but is not required.
• The ideal applicant will be a quick learner and highly motivated to gain new skills.

Job website: http://www.seek.com.au/job/67270679

Contact name: Rebecca Poulos

Contact email: rpoulos@cmri.org.au

Bioinformatician @ AGRF

Position title: Bioinformatician

Employer: Australian Genome Research Facility

Closing date: Sunday 21 May 2023

Brief position description:

Australian Genome Research Facility (AGRF) is a not-for-profit organisation committed to quality and innovation. AGRF provides the gateway to a national network of essential genomic technology, expertise and innovation through our main laboratory operations located at the Victorian Comprehensive Cancer Centre in Melbourne, and laboratories located in Adelaide, Brisbane, Perth and Sydney,

We seek to empower Australia to be recognised for world-class genomics and innovation. By collaborating and sharing our knowledge and expertise, and providing local access to innovative and state-of-the-art genomic technologies, we enable Australian academia and industry to advance leading-edge genomic research internationally. We are a team of dependable, collaborative and innovative thinkers who are empowered to generate and deliver solutions to the scientific community.

About the roles
We are seeking a motivated, talented and experienced Bioinformatician to join our highly skilled Bioinformatics team for this ongoing, full time role. 

In this role you will contribute to the delivery of high-quality bioinformatics services at AGRF providing developing technical expertise for specialist bioinformatics services and providing high-quality and professional client support. This includes delivering of high-quality, standardised analysis using automated and semi-automated analysis pipelines; and custom analysis by following established workflows under supervision of Senior team members.

We encourage applications from suitable candidates who wish to work in Melbourne, Sydney, Adelaide, Brisbane, or Perth as this position can be located at any of our sites. 

What you'll need to succeed

Essential:
PhD in relevant field; or Honours or Masters in Bioinformatics with minimum of 2 years relevant experience; or an equivalent combination of experience and/or training
Lead at least a service at expert levels to independently handle complex custom projects efficiently with high quality results.
Must have competent programming skill (expert level in at least one of Python, Perl, R, shell scripting and/or other relevant languages) working in Linux environment.
Pipeline development.
In-depth knowledge of and experience in high throughput NGS sequencing data analysis
Expert in analysing at least one of the areas: germline/somatic exome/WGS variant calling, RNA-seq, MethylSeq, array analysis, population genetics, etc.
Familiarity with basic concepts in biology.
Familiarity with research design and scientific methods
Strong written and verbal communication skills
Demonstrated ability to work effectively in a service role emphasising client satisfaction
Demonstrated ability to handle tight deadlines and maintain high standards of work

Any of the following is desirable but not essential:
Experience in working with job scheduling systems, such as SLURM and PBS, in HPC clusters
Knowledge of working with version control systems such as Git, SVN
Independently research on new methods and develop efficient maintainable pipelines.
Experience with containers and working in the cloud platform.
Experience in analysing long read sequencing data
Strong knowledge in human genetics

Benefits we can offer you
Attractive remuneration package on offer including 10.5% superannuation, salary packaging benefits, incentive plans and employee benefits discount program.

What you need to do to apply:
If this role is for you we'd love to hear from you.

Please apply with your CV and a cover letter. It is essential that you include a statement addressing each of the selection criteria listed under the 'What you'll need to succeed' section of this job ad as part of your application.

Closing date for applications: Sunday 21 May 2023.

If you have any questions about the roles please contact Karen Jenkins, Head of People and Culture, on 03 9321 3709.

* Please note all applicants must have the right to work in Australia.

** No agencies please

Job website: http://www.agrf.org.au/careers

Contact name: Karen Jenkins

Contact email: Karen.Jenkins@agrf.org.au