Computational RNA Biology Programmer @ Canberra

Employer: The Australian National University

Closing date: 29th November 2023

Brief position description: The John Curtin School of Medical Research (JCSMR) is a leading centre of biomedical research in Australia with research programs addressing fundamental problems of significance to human disease. Within this environment, The Centre for Computational Biomedical Sciences (CCBS) develops advanced computational and medical technologies to enable discovery, interpretation, and prediction in biomedical research. CCBS works in conjunction with The Shine-Dalgarno Centre for RNA Innovation (SDCRI), which aspires to drive impactful discoveries and innovations in RNA science to harness the next generation of RNA-based therapeutics and diagnostics, train and foster the future RNA research workforce, and mobilise this workforce and RNA discoveries to areas of strategic health and economic importance to the region and nation.

The Computational RNA Biology Programmer is expected to undertake work within the CCBS in the context of its activities and collaborations with the SDCRI; and will contribute to the development, application, and evaluation of machine learning methods to improve RNA molecule and delivery vector design.

For further information about this position please contact Professor Eduardo Eyras, Head, Centre for Computational Biomedical Sciences at John Curtin School of Medical Research – E: eduardo.eyras@anu.edu.au

Job website: http://jobs.anu.edu.au/jobs/programmer-computational-rna-biology-canberra-act-act-australia

Contact name: Eduardo Eyras

Contact email: eduardo.eyras@anu.edu.au

Bioinformatician - Cancer Research @ VIC

Employer: Peter MacCallum Cancer Centre

Closing date: 20th November 2023

Brief position description: This position will join the Bioinformatics Core Facility to provide bioinformatics support to next-generation sequencing and other high-throughput genomics data using best-practice methods. This position is a full time one-year, fixed term position with a prospect for a permanent position. Candidates interested in a part-time position are also encouraged to apply and put the relevant information in the cover letter.

The Bioinformatics Core Facility aims to provide all levels of bioinformatics support to research laboratories within Peter Mac. The team of bioinformaticians and engineers at the Core work alongside laboratory and clinical researchers and contribute to their experimental design, grant applications and the analysis and publication of genomic and transcriptomic data. The Core also develops and maintains software infrastructure required for bioinformatics processing, including analysis pipelines, machine learning workflows, and cloud provision systems.

This position will primarily support the bioinformatics analysis of cancer research projects by developing and maintaining analysis pipelines to be used by Peter Mac Research. This position will work and communicate closely with cell biologists, bioinformaticians, software engineers and system admins to address the analytical challenges posed by evolving genomic technologies.

Job website: https://careers.petermac.org/job/MELBOURNE-Bioinformatician-Cancer-Research-VIC-3000/936068810/

Contact name: Richard Lupat

Contact email: richard.lupat@petermac.org

Data and Research Computing Specialist @ SA

Employer: South Australian immunoGENomics Cancer Institute (SAiGENCI) at The University of Adelaide

Closing date: 30th November 2023

Brief position description: Together with the University of Adelaide’s ITDS and Research Computing teams, the South Australian immunoGENomics Cancer Institute (SAiGENCI) is inviting applications to apply for the Data and Research Computing Specialist position. This position will report to the Director, Research Infrastructure and Platforms in the Division of Research and Innovation at The University of Adelaide with an aligned responsibility to the Head, Data Sciences Unit, at The South Australian ImmunoGenomics Cancer Institute (SAiGENCI). 

The South Australian ImmunoGenomics Cancer Institute (SAiGENCI) is located in the AHMS building in Adelaide’s biomedical precinct on North Terrace. SAiGENCI undertakes world class cancer research in cancer biology, computational biology, epigenetics, and immuno-oncology. The Data and Research Computing Specialist will play a key role supporting scientists across the institute to do world-leading research.

Advances in data generation and computational analysis have increased the demand for specialist data management skills and research computing expertise. The reduction in costs of sequencing and the advancement of spatial maps, have led to the increased requirement for specialist data handling and management of big data. Large and complex data sets associated with imaging techniques, such as CosMx and single cell spatial maps, as well as genomic platforms, such as whole genome/exome sequencing and genotype arrays require storage, access, processing and analytical management. 

This role will work broadly with scientists across SAiGENCI to provide support, training and advice that will enable them to make the most of high performance computing resources and data storage options for different types of ‘omics data and imaging data. In addition, they will work closely with the University of Adelaide’s ITDS and Research Computing teams to support scientists at SAiGENCI in the management of the high performance computing requirements and the effective communication of those needs.

Essential:
- Experience in the configuration and management of research computing infrastructure, virtualised environments, etc.
- Experience in supporting the activities of an academic or research community and management of advanced research computing resources.
- Strong technical knowledge of HPC system architecture and software.
- Knowledge or demonstrated expertise in high performance computing with a diverse skill set of singularity, docker, nextflow
- Demonstrated highly developed written and oral communication skills, including ability to liaise and negotiate effectively with a wide and diverse range of people, good report writing skills.
- Understanding of the research computing needs of researchers in medical research including bioinformatics, genomics, biostatistics

Desirable:
- Knowledge of large-scale biological data and methods of data management.
- Demonstrated expertise and fundamental knowledge in biomedical research data management with current technologies including privacy compliance, data repositories, standards in metadata, research methods and research data curation and how data supports high quality research.

Qualification/s:
- Postgraduate qualifications or progress towards postgraduate qualifications and extensive relevant experience (preferably in information management, information technology, computing or data-intensive research discipline); or
- An equivalent combination of relevant experience and/or education/training (in data management or imaging processing)..

Job website: http://careers.adelaide.edu.au/cw/en/job/512920/data-and-research-computing-specialist

Contact name: Belinda Cornes

Contact email: belinda.cornes@adelaide.edu.au

Postdoctoral Fellow - Computational Biology @ VIC

Employer: Peter MacCallum Cancer Centre

Closing date: 13th November 2023

Brief position description: The Trigos lab focuses on understanding how different -omics layers in tumour cells and the microenvironment adapt and co-evolve as an ecosystem to drive cancer progression, resistance and metastasis with the goal of identifying novel biomarkers and targets for treatment. We address these questions using a computational top-down approach to profile patient samples collected from biospecimen collection programs and clinical trials. Throughout our projects we use a combination of bulk, single-cell and spatial -omics data, including genome sequencing, gene expression, methylation, chromatin accessibility, ctDNA, single-cell RNAseq and multiome, as well as spatial transcriptomics and proteomics platforms (e.g. Visium, OPAL, MIBI, CODEX, Nanostring Digital Spatial Profiling). 

We are based in the Computational Biology Program, which is an active community with scientists from a range of disciplines including biology, biomedicine, computer science,mathematics, statistics, as well as software engineering. We collaborate widely with scientists and clinicians in prostate cancer and multiple myeloma, including the Prostate Theranostics Imaging Centre of Excellence (ProsTIC) and the Barrie Dalgleish Centre for Myeloma and Related Blood Cancers.

We are seeking a talented, highly motivated and self-directed Postdoctoral Researcher in Computational Biology with a PhD graduate degree in Bioinformatics, Computational Biology, Genomics, Image Analysis or related. The Postdoctoral Research will lead projects understanding spatial cell-cell interactions from spatial transcriptomics and proteomics data, including the integration with other data modalities. The Postdoctoral Researcher will have the opportunity to develop projects together with the lab head, design and carry out analyses and method development (as required) with unique -omics datasets to address key translational questions. Postdocs will receive mentorship in structuring research manuscripts, writing grant applications, and developing collaborations.

For the full position description, please visit: https://careers.petermac.org/job/MELBOURNE-Postdoctoral-Fellow-Computational-Biology-VIC-3000/945024010/

Contact name: Anna Trigos

Contact email: anna.trigos@petermac.org

Software Engineer - Vaccine Design

Employer: CSIRO

Closing date: 29 October 2023, 11:00 pm AEDT

Brief position description: 

Acknowledgement of Country
CSIRO acknowledges the Traditional Owners of the land, sea and waters, of the area that we live and work on across Australia. We acknowledge their continuing connection to their culture and pay our respects to their Elders past and present. View our vision towards reconciliation

Child Safety
CSIRO is committed to the safety and wellbeing of all children and young people involved in our activities and programs. View our Child Safe Policy.

The Opportunity
Certified Amazon Web Services, Microsoft Azure and/or Google Cloud Platform user
Evidence of data analytics and programming – Python, Java, C++, Scala, BASH, R, Julia
Join CSIRO's AEHRC! A truly collaborative, flexible and inclusive workplace

The Australian e-health research centre (AEHRC) is CSIRO’s digital health research unit delivering innovation to the health system. It is the largest eHealth research group in Australia with more than 100 research scientists working with clinicians and industry to identify the clinical and/or health challenges. AEHRC is worldwide unique in covering the full value chain from basic science through to clinical application and assessing their impacts on Australian and international health systems.

As the Software Engineer Vaccine Design, you’ll join the Transformational Bioinformatics Group within AEHRC to develop novel bioinformatics solutions for research and industry using the latest technologies in cloud infrastructure and will be working closely with the external collaborators and stakeholders to design & architect modular bioinformatics design pipelines and standardised workflows, deployed on cloud computational and storage infrastructure.

You’ll be instrumental in bridging the gap between various bioinformatic pipelines and building a digital platform for designing RNA therapeutics, including vaccines, using cloud infrastructure, leading to the curated workflows which will enable rational modular designing and successive functional improvement of single or multi-component mRNA vaccine or therapeutic candidates. If you are fascinated in this area of research and contribute to novel bioinformatic solution, then do not hesitate to apply.

Your duties will include:
In collaboration with scientists, designing and implementing innovative cloud architecture to carry out impactful research and cater for the challenges in the health and life science domain (fast turn-around-time and large volumes of data).
Implementing ML solutions to biological research questions; Exploring novel ML methodological approaches to research questions.
Be knowledgeable about cloud services across multiple vendors (specifically AWS, Azure, GCP). 
Preparing appropriate documentation through repositories (e.g. bitbucket), project boards (e.g. trello), online communities (e.g. gist) and contributing to reports, scientific papers and blog posts.
Communicating openly, effectively and respectfully with all staff, clients and suppliers in the interests of good business practice, collaboration and enhancement of CSIRO’s reputation and a few other duties appropriate to the role.

Location: Open to any of these locations - Adelaide, SA; Canberra, ACT; Melbourne, VIC; Brisbane, QLD; Sydney, NSW

Salary: AU$105k – AU$114k plus up to 15.4% superannuation

Tenure: Specified term of up to 2 years

Reference: 93397

To be considered you will need:
A bachelor or master degree or equivalent relevant work experience in a relevant discipline area, such as Information Technology, Bioinformatics, Electrical Engineering, or Data Science.
Proven impact from developing solutions on public cloud infrastructure (AWS, Azure, GCP, Alibaba cloud) or advanced high-performance computing (HPC) with demonstrated software engineering practices (use of repositories, deployment standards, efficiency analysis).
Evidence of advanced data analytics and programming capabilities in more than one language relevant to bioinformatics (e.g. Python, Java, C++, Scala, BASH, R, Julia).
High-level written and oral communication skills with the ability to represent the research team effectively internally and externally, including the presentation of research outcomes at national and international conferences.
A sound history of publication in peer-reviewed journals and/or authorship of scientific papers, reports, grant applications or patents.
A record of scientific innovation and creativity, including the ability & willingness to incorporate novel ideas and approaches into scientific investigations.


For full details about this role please review the Position Description

Eligibility
Applications for this position are open to Australian/ New Zealand citizens and Australian permanent residents currently residing in Australia.
Appointment to this role is subject to the provision of a national police check and may be subject to other security/medical/character requirements.

Flexible Working Arrangements
We work flexibly at CSIRO, offering a range of options for how, when and where you work. 

Diversity and Inclusion
We are working hard to recruit people representing the diversity across our society, and ensure that all our people feel supported to do their best work and feel empowered to let their ideas flourish. 

About CSIRO
At CSIRO Australia's national science agency, we solve the greatest challenges through innovative science and technology. We put the safety and wellbeing of our people above all else and earn trust everywhere because we only deal in facts. We collaborate widely and generously and deliver solutions with real impact. 

CSIRO is committed to values-based leadership to inspire performance and unlock the potential of our people.

CSIRO is committed to the safety and wellbeing of all children and young people involved in our activities and programs, whether we are undertaking research, engaging with the public or nurturing future scientists in person or online. Source – CSIRO Child Safe policy 2023

Join us and start creating tomorrow today!

How to Apply
Please apply on-line and provide a cover letter and CV that best demonstrate your motivation and ability to meet the requirements of this role.

Job website: http://jobs.csiro.au/job-invite/93397/

Contact name: Shree Chattopadhyay

Contact email: careers.online@csiro.au

Ataxia Postdoc (bioinformatics) @ VIC

Employer: WEHI

Closing date: 25th October

Brief position description: The Bahlo lab is a computational biology and statistical genetics group that seeks to identify and understand genetic risk factors of human diseases, with a strong focus on neurological and retinal disorders. We leverage cutting-edge computational tools to analyse massive genomic datasets from local and international human disease cohorts to identify genetic variants associated with diseases, integrating these data with multi -omics data to gain biological understanding. Our multi-disciplinary research team collectively have expertise in many aspects of human genetics research, from rare variant analysis to GWAS studies. We have well established collaborations with molecular biologists and clinicians nationally and internationally with access to outstanding genomic cohorts.

We are seeking a highly motivated and self-directed Research Officer to join our research team focused on investigating the genetic basis of ataxia disorders in an Australian adult ataxia cohort. The position is funded by a successful Genomics Mission Medical Research Future Fund grant and continues our previously highly successful work which has led to several gene discoveries and improved diagnostics for ataxia patients.

The successful candidate will be supervised by Dr Haloom Rafehi and Prof. Melanie Bahlo and will collaborate closely with a multidisciplinary team of researchers, including bioinformaticians, molecular biologists and clinicians analysing genomic and other 'omic data from ataxia patient cohorts.

Job website: http://www.seek.com.au/job/70361914

Contact name: Haloom Rafehi

Contact email: rafehi.h@wehi.edu.au

Bioinformatics Research Officer @ VIC

Employer: The University of Melbourne - Doherty Institute

Closing date: 4 October 2023

Brief position description: The Computational Sciences Initiative (CSI) at the Peter Doherty Institute for Infection and Immunity is seeking a skilled Research Fellow to contribute to groundbreaking research under the guidance of Dr. Jan Schroeder. The institute's renowned work on infectious diseases and immunity, notably during the COVID-19 pandemic, underscores its dedication to impactful research. 

As a member of the CSI, the successful candidate will collaborate with diverse research teams, leading bioinformatics projects focused on infectious diseases and immunology. The role's emphasis on multi-omic data analysis, integration, and cutting-edge machine learning techniques offers a unique chance to drive scientific discoveries while contributing to innovative approaches in bioinformatics.

The responsibilities of the role include:

* Assisting the development of a strong program of collaborative research with other groups in the Doherty Institute in bioinformatics.
* Use best-practice pipelines for analysis of bulk, single cell and spatial multi-omic data generated by collaborators.
* Develop new methods and software packages for analysis of genomic, epigenomic, transcriptomic, proteomic and metabolomic sequence data where appropriate.
* Develop and apply machine learning approaches to analyse multi-omics datasets.

Please see the below link for more details, a position description and to apply.

Job website: http://jobs.unimelb.edu.au/en/job/913982/research-officer-bioinformatics

Contact name: Jan Schroeder

Contact email: jan.schroeder@unimelb.edu.au

Research Scientist (Bioinformatics / Computational biology) @ VIC

Employer: Agriculture Victoria

Closing date: 02/10/2023 (Midnight)

Brief position description: Agriculture Victoria Research is seeking to recruit an experienced Research Scientist for a Bioinformatics / Computational biology research position. This fulltime role will require a high level of analytical skills and knowledge, with extensive experience in bioinformatics or computational biology, especially in the analysis of high-throughput DNA sequencing data for metabarcoding and/or metagenomic identification of species. The position will support the research activities defined in the National Grains Diagnostics and Surveillance Initiative (NGDSI) - Grains Biosecurity Mission (GBM) which is co-funded by Grains Research and Development Corporation (GRDC). 

The position will be based at the AgriBio Centre, in Bundoora (Melbourne), in the Invertebrate and Weed Sciences group, which delivers research in integrated pest management, invertebrate diagnostics and surveillance, weed management and biological control of invertebrate pests and weeds. Many of the duties will require initiative and independent work. The applicant will have a good aptitude for working as part of a large multidisciplinary team, conducting a wide variety of work across the Microbial Sciences, Pests and Diseases unit.

Specialist/Technical Expertise/Qualifications:
• A PhD or equivalent in a relevant discipline including bioinformatics, computational biology, genomics

This is a fixed term position available for a period of 3 years. The work location for this position is Bundoora with hybrid work arrangements available.

To be considered for this position, applicants should respond to the key selection criteria and submit a resume. For further information please refer to position description on the job website.

Job website: http://careers.vic.gov.au/job/research-scientist-753645

Contact name: Alexander Piper

Contact email: alexander.piper@agriculture.vic.gov.au

Senior Scientist, Translational Bioinformatics @ VIC

Employer: CSL Limited

Closing date: 29th of September 2023

Brief position description: 
We have an opportunity available for a Senior Scientist, Translational Bioinformatics to join our Research Data Science team. In this newly created position, you will provide scientific and technical expertise to help answer biomedical research questions at the pre-clinical and clinical stage of drug development using advanced bioinformatics.

You will expand CSL’s R&D capability in Translational Bioinformatics in order to derive biological insights from large-scale multi-omic data available in public and commercial databases, as well as generated from in-house high-throughput sequencing and other omic experiments. These analyses will help answer questions in areas of key importance to CSL’s drug development pipeline, including asset positioning, biomarker discovery, understanding drug mechanisms of action, identifying new drug candidates, and patient stratification.

Reporting to the Senior Manager, Translational Bioinformatics, you will work closely with scientists within the Data Science Group, the Translational Science Group and other Research and Clinical Development groups to set project objectives and to determine and implement data generation, data analytics, and bioinformatics platform development strategies.

You will also work alongside CSL’s external collaborators including spending time in their research laboratories as required to enable alignment of objectives and bioinformatic strategies.

Your Skills & Experience:

PhD in bioinformatics, computational biology, computer science, or a related discipline, with significant computational and biomedical components.
3+ years of post-doctoral experience in biomedical data analytics in a highly collaborative, interdisciplinary environment in academia and/or industry with a focus on translational research.
Experience in analysing RNASeq datasets and working with life scientists to draw statistically solid biological insights from data.
Experience in genomic variant analysis on patient cohorts and/or utilizing genomic variant data from public databases to understand mechanism of action of targets, drug candidates or diseases and support translational biomarkers.
Experience in applying network biology and pathway analysis algorithms (using open source and/or commercial tools, e.g. IPA).
Experience in using public databases to answer key research questions related to experimental design, biomarker discovery and patient stratification (e.g., gene expression databases, clinical variants, etc.).
Experience in working in a Unix-like and high-performance computing (HPC) environment using Python, R and other scientific computing languages.
Apply now to join Australia’s leading biopharmaceutical company, committed to protecting public health!

Applications Close on 29th of September

Please include an up-to-date CV and Cover Letter addressing selection criteria.

About Us

Our Benefits

We encourage you to make your well-being a priority. It’s important and so are you. Learn more about how we care at CSL.

About CSL

CSL is a leading global biotechnology company with a dynamic portfolio of life-saving medicines, including those that treat haemophilia and immune deficiencies, as well as vaccines to prevent influenza. Since our start in 1916, we have been driven by our promise to save lives through innovation. Learn more about CSL.

We want CSL to reflect the world around us

As a global organisation with employees in 35+ countries, CSL embraces diversity, equity and inclusion. Learn more about Diversity, Equity & Inclusion at CSL.

Do work that matters at CSL!

Job website: http://csl.recsolu.com/jobs/mOcsxYVaimqryuNNf3-JTw/job_boards/rAD_La6OkYhQxVTHz3rLgA

Contact name: Arthur Hsu

Contact email: Arthur.Hsu@csl.com.au

Postdoctoral Fellow (Virology) @ NSW

Position title: Postdoctoral Fellow (Virology)

Employer: UNSW

Closing date: 20th September 2023 before 11.30pm

Brief position description: The Post-Doctoral Fellow will contribute to research projects within the UNSW-affiliated Virology Research Laboratory, based at the Prince of Wales Hospital. They will contribute to the NHMRC-funded investigation of the pregnancy and early life virome (population of all viruses infecting humans) dynamics and its potential contribution to chronic diseases (e.g., type 1 diabetes, coeliac disease, asthma and allergy).

The position will involve completing research tasks related to these projects, critically appraising genomic data through in-depth bioinformatics analyses, supervising research assistants and students, contributing to competitive research grants and preparing data for peer-review publication.

Employment Type: Full - time (35 hours a week) 
Duration: 1-Year Fixed Term contract (with possible 2-year extension)
Remuneration: Up to $106,337 p.a. (+17% super and leave loading)
Location: Prince of Wales Hospital, Randwick, NSW

Job website: https://external-careers.jobs.unsw.edu.au/cw/en/job/519215/postdoctoral-fellow-virology

Contact name: Merita O Connell

Contact email: merita.oconnell@unsw.edu.au