Position title: Senior/Research Scientist - Translational Bioinformatics
Employer: CSL Limited
Closing date: June 7, 2020
Brief position description: We have an opportunity available for a Senior/Research Scientist, Translational Bioinformatics to join our Research team located at Bio21 Institute. In this position, you will provide scientific and technical expertise to help answer biomedical questions at the pre-clinical and clinical stage of drug development using advanced bioinformatic methods. You will expand CSL’s research capability by supporting the Global Translational Science group in order to derive biological insights from in-house high-throughput sequencing data and large-scale genomic data available in public and commercial databases. Furthermore, you will devise an integrative approach to analyze multiple types of data obtained from in-house and external resources in order to answer key questions in the areas of biomarker discovery and understanding of mechanisms of action of targets, drug candidates and diseases of interest.
Working closely with the Data Science Group, the Translational Science Group and other Research, you will set project objectives and determine and implement data generation, analysis and software development strategies. You will also work alongside CSL’s external collaborators including spending time in their research laboratories as required to enable alignment of objectives and strategies for bioinformatics methods.
Reporting into the Senior Manager Bioinformatics & AI in the Global Research Data Science Group, you will be responsible to:
Provide input into thedesign of next-generation sequencing experiments including RNA-seq, DNA-seq, Rep-seq, etc.
Carry outbioinformatic analyses on datasets generated in-house from different NGS and array experiments or collected from external databases.
Contribute to theinterpretation and reporting of the biological insights derived from data analytics based on GSP guidelines.
Work with the Translational Science group to establish an in-house capability toutilize genetic and genomic variants in order to improve biomarker discovery, understanding of MoA, patient stratification strategies and prioritisation of indications for drug targets.
Work with the Translational Science group tobenchmark and adapt new sequencing technologies (e.g. long read and single cell sequencing) in order to answer challenging research questions across multiple drug discovery projects.
Work with the Translational Science group tointegrate data from external databases (e.g., GTEx, ExAC, ENCODE, UK Biobank) into CSL Research computational platforms and improve upon current data mining practices.
Work with in-house software developers to develop fullyautomated workflows that help accelerate Translational Science data processing activities.
Work with Research and IT data managers in order todevise new processes for managing translational data and ensure compliance with CSL’s regulatory requirements (e.g., Good Scientific Practices, etc.).
Contribute toCSL’s growing collaboration network with academic laboratories and industry partners locally and globally.
Job website: http://www.linkedin.com/jobs/view/1868364147/
Contact name: Sophie Saba
Contact email: Sophie.Saba@csl.com.au